Exploring the Anticancer Potential of Dendrobium Hybrid Extracts on Melanoma Proliferation and Oxidative Stress Modulation

Abstract

This study investigates the anticancer potential of extracts from the Dendrobium Pearl Vera hybrid (DH) on melanoma cell proliferation. The propanolic extract (DH-P), rich in phenolics and flavonoids, demonstrated significant inhibition of melanoma cell growth through mechanisms involving oxidative stress modulation and apoptosis induction. Key phytochemicals such as quercetin, 5-hydroxymethyl-2-furaldehyde (5-HMF), and dendrobine were identified in DH-P, contributing to its strong bioactivity. The extract exhibited a dual role in both suppressing cancer cell proliferation and protecting normal cells from oxidative damage. These findings suggest that DH extracts, especially DH-P, hold promise as plant-based therapies for melanoma. Further in vivo studies and clinical investigations are recommended to evaluate their therapeutic efficacy and safety.